Publications

2019

Cowgill, J., Klenchin, V.A., Alvarez-Baron, C.P., Tewari, D., Blair, A., Chanda, B.; “Biploar switching by HCN voltage sensor underlies hyperpolarization activation”, Proceedings of the National Academy of Sciences (USA), January 2018, 

2018

Alvarez-Baron, C.P., Klenchin, V.A., Chanda, B.;  “Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family”, 

Fernández-Mariño, A.I., Harpole, T.J., Oelstrom, K., Delemotte, L., and Chanda, B.;  “Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel”, Nature Structural & Molecular Biology, 25, 320-326. DOI: 10.1038/s41594-018-0047-3. Article Link.

Bao, H., Das, D., Courtney, N.A., Jiang, Y., Briguglio, J.S., Lou, X., Roston, D., Cui, Q., Chanda, B., and Chapman, E.R.; “Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties”, Nature 554, 260. DOI: 10.1038/nature25481. Article Link.

2017

Goldschen-Ohm, M.P., Chanda, B.; “SnapShot: Channel Gating Mechanisms”, Cell, Volume 170, Issue 3, 2017, Pages 594-594.e1, ISSN 0092-8674, http://dx.doi.org/10.1016/j.cell.2017.07.019. Article Link.

Zhao, Y., Goldschen-Ohm, M.P., Morais-Cabral, J.H., Chanda, B., and Robertson, G.A.; “The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation”. Journal of General Physiology DOI:10.1085/jgp.201611701. Article Link.

Goldschen-Ohm, M.P., White, D., Klenchin, V., Chanda. B., and Goldsmith, R.; “Observing single molecule dynamics at millimolar concentrations”, Angew. Chem. Int. Ed. DOI:10.1002/anie.201612050. Article Link.

2016

Ahern, C.A., Payandeh, J.P., Bosmans, F., and Chanda, B.; “The hitchhiker’s guide to the voltage-gated sodium channel galaxy”,  Journal of General Physiology 147 (1): 1-24. Article Link.

Oelstrom, K., Chanda, B.; “Congruent pattern of accessibility identifies minimal pore gate in a nonsymmetric voltage-gated sodium channel”, Nature Communications DOI:10.1038/ncomms11608. Article Link.

Goldschen-Ohm MP, Klenchin VA, White DS, Cowgill JB, Cui Q, Goldsmith RH, Chanda B.;  “Structure and dynamics underlying elementary ligand binding events in human pacemaking channels”, Elife. 2016 Nov 18;5PubMed PMID: 27858593; PubMed Central PMCID: PMC5115869Article Link.

2015

Bao, H., Goldschen-Ohm, M., Jeggle, P., Chanda, B., Edwardson, J.M., Chapman, E.R.;  “Exocytotic fusion pore are composed of both lipids and proteins”, Nature Structural and Molecular Biology 23, 67-73  | doi:10.1038/nsmb3141. PDF

  • Highlighted in “The mystery of the fusion pore” by Satyan Sharma and Manfred Lindau, (ibid. Pgs. 5-6). PDF

2014

Chowdhury, S., Haehnal, B.M., and Chanda, B.; “Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels”, Journal of General Physiology 144:457-467. PDF

Chowdhury, S., Haehnal, B.M., and Chanda, B.; “A self-consistent approach for determining pairwise interactions that underlie channel activation”, Journal of General Physiology 144: 441-455. PDF

Chowdhury, S., Jarecki, B.W., Chanda, B.; ” A Molecular framework for temperature-dependent gating of ion channels”,  Cell 158, 1148-1158. PDF

  • Highlighted in “Building a temperature-sensitive ion channel” by Ming-Feng Tsai and Christopher Miller, (ibid. Pgs. 977-979). PDF
  • A video abstract was featured as PaperFlick in the online issue.

Oelstrom K.M., Goldschen-Ohm, M.P., Holmgren, M., Chanda, B., “Evolutionarily conserved intracellular gate of voltage-gated sodium channels”, Nature Communications DOI:10.1038/ncomms4420. PDF

Jarecki, B.W., Zheng, S.L., Zhang, L., Li, X., Zhou, X., Cui, Q., Tang, W., Chanda, B.,  “Tethered spectroscopic probes estimate dynamic distances with sub-nanometer resolution in voltage-dependent potassium channels”, Biophysical Journal 105(12) 2724-2732. PDF

  • Featured in research highlights section in Nature Chemical Biology March 2014 (pg. 169).
  • Highlighted in “New rule(r)s for FRET”  by Frank Bosmans, (ibid. Pgs. 2619-2620). PDF

2013

Capes, D.L., Goldschen-Ohm, M.P., Arcisio-Miranda, M. Bezanilla, F., Chanda, B., “Domain IV voltage-sensor is both sufficient and rate-limiting for fast inactivation in sodium channels. Journal of General Physiology 142 (2), 101-112. PDF

  • Highlighted in “What activates inactivation?”  by Christopher Ahern, (ibid. Pgs. 97-100). PDF

Goldschen-Ohm, M.P., Capes, D.L., Oelstrom, K., Chanda, B., “Multiple pore conformations driven by asynchronous movements of voltage-sensors in a eukaryotic sodium channel”, Nature Communications 4:1350. doi: 10.1038/ncomms2356. PDF

Jarecki, B.W., Makino, S., Beebe, E., Fox, B., Chanda, B., “Function of Shaker potassium channels produced by cell-free translation upon injection into Xenopus oocytes. Scientific Reports 3:1040. doi: 10.1038/srep01040. PDF

Chowdhury, S., Chanda, B., “Free energy relationships in ion channels activated by voltage and ligand”, Journal of General Physiology. 141(1): 11-28. PDF

  • Highlighted in “No model in mind: A model-free approach for studying ion channel gating” by Ofer Yifrach (ibid. Pgs. 3-9). PDF

2012

Capes, D., Arcisio-Miranda, M., Jarecki, B.W., French, R., Chanda, B., “Gating transitions in the selectivity filter region of a sodium channel are coupled to domain IV voltage-sensor”,  Proceedings of the National Academy of Sciences (USA) 109(7): 2648-53. PDF

  • Highlighted in “Enhancement of closed-state inactivation by neutralization of S4 arginines in domain IV of a sodium channel” by Tzur Paldi (Frontiers in Pharmacology (2012) doi:10.3389/fphar.2012.00143 ) PDF

Chowdhury, S., Chanda, B., “Estimating the voltage-dependent free energy change of ion channels using the median voltage of activation”, Journal of General Physiology 139 (1): 3-17. PDF

  • Highlighted in “Model-free energy for voltage-gated ion channels” by Christopher Miller (ibid. Pgs 1-2). PDF
  • Also highlighted in “Taking a thermodynamic approach: A conversation with Baron Chanda” by Elizabeth Adler (Journal of General Physiology vol. 144, no.2, Pg.127)

2010

Chowdhury, S., Chanda, B., “Deconstructing thermodynamic parameters from site-specific observables in a coupled system”, Proceedings of the National Academy of Sciences (USA)  107(44), 18856-18861. PDF

Arcisio-Miranda, M., Muroi, Y., Chowdhury, S., Chanda, B., “Molecular basis of allosteric modification of voltage-dependent gating by local anesthetics”, Journal of General Physiology 136(5), 541-554. PDF

Wang, D., Zhang, Z., Chanda, B., and Jackson, M. “Improved probes for hybrid voltage sensor imaging”, Biophysical Journal 99, 2355-2366. PDF

Muroi, Y., Arcisio-Miranda, M., Chowdhury, S., Chanda, B., “Molecular determinants of coupling between the domain III voltage-sensor and pore of a sodium channel”, Nature Structural and Molecular Biology 17, 230-237. PDF

2009

Muroi, Y., Chanda, B., “Local anesthetics disrupt energetic coupling between voltage-sensors of the sodium channel”, Journal of General Physiology 133, 1-15. PDF

2008

Campos, F., Chanda B., Baeiro, P., and Bezanilla, F. “α-scorpion toxin impairs a conformational change that leads to fast inactivation of the sodium channels”, Journal of General Physiology 132, 251-62. PDF

Kumari, S., Borroni, V., Chaudhary, A., Chanda, B., Massol, R., Mayor, S., and Barrantes, F.J. “The nicotinic acetylcholine receptor is internalized via a rac-dependent, dynamin-independent endocytic pathway”, Journal of Cell Biology 181, 1179-1193. PDF

2007

Campos, F., Chanda, B., Baeiro, P., and Bezanilla, F., “b-scorpion toxin modifies gating transitions in all four voltage-sensors of the sodium channel”, Journal of General Physiology 130, 257-268. PDF

Campos, F., Chanda, B., Roux, B. and Bezanillla, F., “Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 in the closed state of the Shaker K channel”,  Proceedings of the National Academy of Sciences (USA) 104(19), 7904-7909. PDF

2006

Ben-Chaim, Y., Chanda, B., Bezanilla, F., Dascal, N., Parnas, I. and Parnas, H., “Movement of “gating charge” is coupled to ligand binding in a G-protein coupled receptor”,  Nature 444 (7115), 106-109. PDF

  • Featured in a commentary “Voltage sparks GPCR” by Peter Stanfield. Nature cell Biology 8;1323-1325 (2006). PDF