Publications

2018

Fernández-Mariño, A.I., Harpole, T.J., Oelstrom, K., Delemotte, L., and Chanda, B. (2018). Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel. Nature Structural & Molecular Biology 25, 320-326. DOI: 10.1038/s41594-018-0047-3. PDF

Bao, H., Das, D., Courtney, N.A., Jiang, Y., Briguglio, J.S., Lou, X., Roston, D., Cui, Q., Chanda, B., and Chapman, E.R. (2018). Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties. Nature 554, 260. DOI: 10.1038/nature25481. PDF

2017

Marcel P. Goldschen-Ohm, Baron Chanda, SnapShot: Channel Gating Mechanisms, Cell, Volume 170, Issue 3, 2017, Pages 594-594.e1, ISSN 0092-8674, http://dx.doi.org/10.1016/j.cell.2017.07.019. PDF

Zhao, Y., Goldschen-Ohm, M.P., Morais-Cabral, J.H., Chanda, B., and Robertson, G.A. (2017) The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation. Journal of General Physiology DOI:10.1085/jgp.201611701. PDF

Goldschen-Ohm, M.P., White, D., Klenchin, V., Chanda. B., and Goldsmith, R. (2017) Observing single molecule dynamics at millimolar concentrations. Angew. Chem. Int. Ed. DOI:10.1002/anie.201612050. PDF

2016

Ahern, C.A., Payandeh, J.P., Bosmans, F., and Chanda, B. (2016) The hitchhiker’s guide to the voltage-gated sodium channel galaxy. Journal of General Physiology 147 (1): 1-24. PDF

Oelstrom, K., and Chanda, B. (2016) Congruent pattern of accessibility identifies minimal pore gate in a nonsymmetric voltage-gated sodium channel.Nature Communications DOI:10.1038/ncomms11608. PDF

Goldschen-Ohm MP, Klenchin VA, White DS, Cowgill JB, Cui Q, Goldsmith RH, Chanda B. Structure and dynamics underlying elementary ligand binding events in human pacemaking channels. Elife. 2016 Nov 18;5PubMed PMID: 27858593; PubMed Central PMCID: PMC5115869. PDF 

2015

Bao, H., Goldschen-Ohm, M., Jeggle, P., Chanda, B., Edwardson, J.M., Chapman, E.R., (2015) Exocytotic fusion pore are composed of both lipids and proteins. Nature Structural and Molecular Biology 23, 67-73  | doi:10.1038/nsmb3141. PDF

  • Highlighted in “The mystery of the fusion pore” by Satyan Sharma and Manfred Lindau, (ibid. Pgs. 5-6). PDF

2014

Chowdhury, S., Haehnal, B.M., and Chanda, B. (2014) Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels. Journal of General Physiology 144:457-467. PDF

Chowdhury, S., Haehnal, B.M., and Chanda, B. (2014) A self-consistent approach for determining pairwise interactions that underlie channel activation. Journal of General Physiology 144: 441-455. PDF

Chowdhury, S., Jarecki, B.W., and Chanda, B. (2014) A molecular framework for temperature-dependent gating of ion channels. Cell 158, 1148-1158. PDF

  • Highlighted in “Building a temperature-sensitive ion channel” by Ming-Feng Tsai and Christopher Miller, (ibid. Pgs. 977-979). PDF
  • A video abstract was featured as PaperFlick in the online issue.

Oelstrom K.M., Goldschen-Ohm, M.P., Holmgren, M., and Chanda, B. (2014) Evolutionarily conserved intracellular gate of voltage-gated sodium channels. Nature Communications DOI:10.1038/ncomms4420. PDF

Jarecki, B.W., Zheng, S.L., Zhang, L., Li, X., Zhou, X., Cui, Q., Tang, W., and Chanda, B. (2013) Tethered spectroscopic probes estimate dynamic distances with sub-nanometer resolution in voltage-dependent potassium channels. Biophysical Journal 105(12) 2724-2732. PDF

  • Featured in research highlights section in Nature Chemical Biology March 2014 (pg. 169).
  • Highlighted in “New rule(r)s for FRET”  by Frank Bosmans, (ibid. Pgs. 2619-2620). PDF

2013

Capes, D.L., Goldschen-Ohm, M.P., Arcisio-Miranda, M. Bezanilla, F. and Chanda, B. (2013) Domain IV voltage-sensor is both sufficient and rate-limiting for fast inactivation in sodium channels. Journal of General Physiology 142 (2), 101-112. PDF

  • Highlighted in “What activates inactivation?”  by Christopher Ahern, (ibid. Pgs. 97-100). PDF

Goldschen-Ohm, M.P., Capes, D.L., Oelstrom, K., and Chanda, B. (2013) Multiple pore conformations driven by asynchronous movements of voltage-sensors in a eukaryotic sodium channel. Nature Communications 4:1350. doi: 10.1038/ncomms2356. PDF

Jarecki, B.W., Makino, S., Beebe, E., Fox, B., and Chanda, B. (2013) Function of Shaker potassium channels produced by cell-free translation upon injection into Xenopus oocytes. Scientific Reports 3:1040. doi: 10.1038/srep01040. PDF

Chowdhury, S., and Chanda, B. (2013) Free energy relationships in ion channels activated by voltage and ligand. Journal of General Physiology. 141(1): 11-28. PDF

  • Highlighted in “No model in mind: A model-free approach for studying ion channel gating” by Ofer Yifrach (ibid. Pgs. 3-9). PDF

2012

Capes, D., Arcisio-Miranda, M., Jarecki, B.W., French, R., and Chanda, B. (2012) Gating transitions in the selectivity filter region of a sodium channel are coupled to domain IV voltage-sensor. Proceedings of the National Academy of Sciences (USA) 109(7): 2648-53. PDF

  • Highlighted in “Enhancement of closed-state inactivation by neutralization of S4 arginines in domain IV of a sodium channel” by Tzur Paldi (Frontiers in Pharmacology (2012) doi:10.3389/fphar.2012.00143 ) PDF

Chowdhury, S., and Chanda, B. (2012) Estimating the voltage-dependent free energy change of ion channels using the median voltage of activation.Journal of General Physiology 139 (1): 3-17. PDF

  • Highlighted in “Model-free energy for voltage-gated ion channels” by Christopher Miller (ibid. Pgs 1-2). PDF
  • Also highlighted in “Taking a thermodynamic approach: A conversation with Baron Chanda” by Elizabeth Adler (Journal of General Physiology vol. 144, no.2, Pg.127)

2010

Chowdhury, S., and Chanda, B. (2010) Deconstructing thermodynamic parameters from site-specific observables in a coupled system. Proceedings of the National Academy of Sciences (USA)  107(44), 18856-18861. PDF

Arcisio-Miranda, M., Muroi, Y., Chowdhury, S., and Chanda, B. (2010) Molecular basis of allosteric modification of voltage-dependent gating by local anesthetics. Journal of General Physiology 136(5), 541-554. PDF

Wang, D., Zhang, Z., Chanda, B., and Jackson, M. (2010) Improved probes for hybrid voltage sensor imaging. Biophysical Journal 99, 2355-2366. PDF

Muroi, Y., Arcisio-Miranda, M., Chowdhury, S., and Chanda, B. (2010) Molecular determinants of coupling between the domain III voltage-sensor and pore of a sodium channel. Nature Structural and Molecular Biology 17, 230-237. PDF

2009

Muroi, Y., and Chanda, B. (2009) Local anesthetics disrupt energetic coupling between voltage-sensors of the sodium channel. Journal of General Physiology 133, 1-15. PDF

2008

Campos, F., Chanda, B., Baeiro, P., and Bezanilla, F. (2008) α-scorpion toxin impairs a conformational change that leads to fast inactivation of the sodium channels. Journal of General Physiology 132, 251-62. PDF

Kumari, S., Borroni, V., Chaudhary, A., Chanda, B., Massol, R., Mayor, S., and Barrantes, F.J. (2008) The nicotinic acetylcholine receptor is internalized via a rac-dependent, dynamin-independent endocytic pathway. Journal of Cell Biology 181, 1179-1193. PDF

2007

Campos, F., Chanda, B., Baeiro, P., and Bezanilla, F. (2007) b-scorpion toxin modifies gating transitions in all four voltage-sensors of the sodium channel. Journal of General Physiology 130, 257-268. PDF

Campos, F., Chanda, B., Roux, B. and Bezanillla, F. (2007) Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 in the closed state of the Shaker K channel. Proceedings of the National Academy of Sciences (USA) 104(19), 7904-7909. PDF

2006

Ben-Chaim, Y., Chanda, B., Bezanilla, F., Dascal, N., Parnas, I. and Parnas, H. (2006) Movement of “gating charge” is coupled to ligand binding in a G-protein coupled receptor. Nature 444 (7115), 106-109. PDF

  • Featured in a commentary “Voltage sparks GPCR” by Peter Stanfield. Nature cell Biology 8;1323-1325 (2006). PDF