Featured Research

Temperature Gating in Ion Channels: A Video Abstract (12/16/2016)

The journal Cell published a video abstract to accompany out study describing the design principles for creating temperature-sensitive ion channels.

Cracking Tough Nuts (8/28/2014)

Ming-Feng Tsai and Christopher Miller summarize our recent work as, “Chowdhury and colleagues report thermodynamics-inspired experiments that productively attack a long-lingering problem in sensory neurobiology: how certain ion channel proteins achieve the exquisite thermosensitivity that allows the neurons housing them—and us—to detect changes in temperature.”  Read more from Tsai’s commentary in “Building a Temperature-Sensitive Ion Channel.”

Podcast Interview with Baron Chanda (7/28/2014)

Baron Chanda was interviewed on Sounds Physiological, a podcast focusing on groundbreaking discoveries in cellular and molecular physiology from the Journal of General Physiology.

Commentary on tethered spectroscopic blockers by Frank Bosmans (12/17/2013)


Frank Bosmans wrote a commentary of our article, “Tethered spectroscopic probes estimate dynamic distances with subnanometer resolution in voltage-dependent potassium channels,” where he compared the tether length to a dog leash.  Longer tethers allow the dog to quench the fluorophore bone, and shorter ones do not.  Bosman’s article is titled, “New rule(r)s for FRET.

“Systematic Investigation,” commentary from C. Ahern (7/5/2013)

Christopher A. Ahern summarizes our recent paper as a “voltage sensor–disabling approach to systematically investigate the identity of the molecular trigger for inactivation and confirm the role for the domain four (DIV S4) voltage sensor in this key physiological process.” Read more in Ahern’s commentary article, “What activates inactivation?

Estimating the free energy change: JGP Video Abstract (12/20/2012)

The Journal of General Physiology published a video abstract for our lab describing how we estimate the free energy change for ion channels. This video relates to our article:

Chowdhury, S., and Chanda, B. (2012) Estimating the voltage-dependent free energy change of ion channels using the median voltage of activation.Journal of General Physiology 139 (1): 3-17.

Linkage analysis toolkit by Dan Sigg (12/20/2012)

An introductory video on Linkage analysis by our collaborator, Dan Sigg. This video abstract accompanied two back to back articles in the Journal of General Physiology on the application of Linkage analysis to probe molecular basis of allosteric interactions.

Chowdhury, S. and Chanda, B. (2013) Free-energy relationships in ion channels activated by voltage and ligand.Journal of General Physiology 141(1): 11–28.

Sigg, D (2013) A linkage analysis toolkit for studying allosteric networks in ion channels. Journal of General Physiology 141(1): 29–60.

“Rigorous Thermodynamic Formalisms” (12/17/2012)


Ofer Yifrach talks about our recent article in his commentary, “No model in mind: A model-free approach for studying ion
channel gating,” in the Journal of General Physiology.

“Elegant Analysis,” commentary on our article. (12/12/2011)

Christopher Miller puts our recent article in a broader context in his commentary, “Model-free free energy for voltage-gated channels,” in the Journal of General Physiology.