The Chanda lab welcomes our two new undergraduate researchers in the lab! Stephan is a senior undergraduate in biochemistry and Owen is sophomore majoring in physics (and maybe mathematics, too). Both will be working with Ruohan and David on various aspects of the single-molecule projects in the lab.
New JGP paper now online! In this study, Dr. Claudia Alvarez-Baron and Dr. Vadim A. Klenchin explore what underlies the molecular basis for increased cAMP efficacy in HCN2 channels using a mutagenesis, electrophysiology, and kinetic modeling. See the paper here!
Our new publication in Nature Structural and Molecular Biology is now online! This study was led by Dr. Ana I. Fernandez-Marino and aided by a fruitful collaboration with Dr. Lucie Delemotte lab at KTH Royal Institute of Technology, Solna, Sweden. See the paper here.
The SMPH Tenure Track Promotions Committee met and recommended that Dr. Baron Chanda be promoted to Professor. Congratulations, Baron!
The Chanda lab is excited to welcome two new additions to the group! Debanjan joins us a doctoral researcher and Nandinin as a research intern!
After a semester study in Paris, Alex, an undergrad in the lab, has suffered enough with the wine and happily came back for the fascinating science (and beer). Welcome back Alex, we miss you!
Second collaboration between Ed Chapman’s lab and Chanda lab led by Huan and Debasis of Chapman lab gets to Nature. Yihao from Chanda lab helps with developing the single fusion pore recording. Fresh online, take a look!
It is bittersweet for the Chanda lab to say farewell to our Dr. Marcel P. Goldschen-Ohm as he begins the next step in his career as an Assistant Professor of Neuroscience at the University of Texas-Austin! Marcel joined the Chanda lab in September of 2009 and has had many scientific accomplishments, specifically in the use of single-molecule methods to probe ion channel gating. We wish the best with your new position. You will be missed!
Visit Marcel’s lab page here.
The Chanda lab is happy to welcome our first year rotation students Wu Lanxi (Biophysics Program) and Alex Duckworth (IPIB)!
The Chanda lab is thrilled to welcome our newest post-doc, Ruohan Zhang! Ruohan comes from ASU where he did his PhD under Dr. Timoth Steimle using spectroscopic methods to study the rotational and vibrational structures of small metal-containing molecules in the gas phase. Ruohan joins David in being jointly advised between Baron and Randall Goldsmith and aims to use single-molecule spectroscopic measurements to reveal the dynamics of ion channels.
The Chanda lab bids farewell to Alex as he begins his semester abroad in France. Safe travels!
A recent interview with Baron from the Biophysical Journal is now online! Baron is an editor for Biophysical Journal’s Channels and Transporters section. PDF
The Chanda lab welcomes a new summer rotation student, Stanford Mitchell. Stanford will be (officially) starting at UW-Madison this upcoming fall semester in the Molecular and Cellular Pharmacology program.
John has been awarded a Predoctoral Fellowship from UW’s Cardiovascular Research Center (CVRC). Congratulations!
The Chanda welcomes our new summer student, Aindrila Saha! Aindrila is a student through the Khorna Program and will be working with Claudia in the lab to studying the gating mechanisms of HCN channels.
Our undergraduate researcher Alex Blair has been awarded the Hilldale Undergraduate Research Award! Way to go Alex!
Friend and fellow ion channel enthusiast Dr. Teresa Giraldez Fernandez from the Department of Biomedical Research Universidad de La Laguna visits Madison! In addition to giving a fantastic talk, she was treated to a day out ice fishing with the lab! See photos here!
Marcel Goldschen-Ohm has definitely been busy! Among writing many of his own papers, he found the time review a number many as well for the Journal of General Physiology- more so than any other postdoctoral reviewer! Here, JGP Editor-in-Chief Sharona E. Gordono presents Marcel with an award for Postdoctoral Reviewer for Reviewed the Most Manuscripts in 2016 for the Journal of General Physiology.
The Chanda group attends the 61st Annual Biophysical Society Meeting in New Orleans, Louisiana! Check out our gallery from the week in NOLA here!
Marcel’s and David’s Angewandte Chemie paper (International Edition) is now available online.
The journal Cell published a video abstract to accompany out study describing the design principles for creating temperature-sensitive ion channels.
The Chanda group is pleased to welcome a new graduate student – Prasanth Kumar! Welcome!
Claudia is a proud recipient of the American Heart Association Postdoctoral Fellowship! Great job Claudia!!
Co-first authors Marcel and Dima publish their paper in eLIFE where they combine single-molecule binding dynamics and a novel crystal structure to understand how cAMP binds to monomeric cyclic nucleotide binding domains of HCN2 channels. This also marks the first paper for both John and David from the lab! Congratulations all!
We bid farewell to our postdoc Ana over drinks and food at the Great Dane Pub! Ana will be starting a second postdoctoral fellowship in the lab of Kenton Swartz at NIH. We will miss you Ana and best of luck!
Meghan joins the lab as an undergraduate researcher!
We are sad to see our undergraduate lab technican Zach leave but are happy to welcome his replacement, Natalie! Natalie is a first year undergraduate student in pursuit of biomedical engineering. Welcome Natalie!
NTP Neuroscience Retreat
Summer BBQ at Baron’s house with friends and colleagues from UW.
Claudia John and Baron at GRC
The Chanda lab enjoys a day sailing on Lake Mendota captained by our very own undergraduate Alex!
The Chanda lab visits Union South for a day of cake, beer, and bowling!
Kevin has successfully defended his PhD thesis titled “Understanding the Gating Mechanisms of Voltage-dependent Sodium and Potassium Channels”. Kevin will soon be starting his new position at Ceullar Dynamics International with former Chanda lab member, Brian. Congratulations Kevin! You will be greatly missed!
David White has joined the lab from the Neuroscience Training Program and will be jointly-advised by Baron and Randall Goldsmith from the Department of Chemistry. Welcome David!
Alex Blair joins the lab as an undergraduate researcher! Alex is a sophmore majoring in Biology.
Marcel’s commetary “How to open a proton-pore more than S4” has been published in Nature Structural and Molecular Biology
Hongbo Chen joins the Chanda lab as a co-advised student with Katherine Henzler-Wildmann. Hongbo will be using NMR to tease apart ion channel structure-function. Welcome!
The Chanda lab is happy to welcome two new graduate students from the Biophysics Graduate Program- John Cowgill and Yihao Jiang!
The Chanda lab goes laser tagging!!
Dr. Claudia P. Alvarez-Baron joins the group as a postdoctoral fellow! Welcome!
Ming-Feng Tsai and Christopher Miller summarize our recent work as, “Chowdhury and colleagues report thermodynamics-inspired experiments that productively attack a long-lingering problem in sensory neurobiology: how certain ion channel proteins achieve the exquisite thermosensitivity that allows the neurons housing them—and us—to detect changes in temperature.” Read more from Tsai’s commentary in “Building a Temperature-Sensitive Ion Channel.”
Baron Chanda was interviewed on Sounds Physiological, a podcast focusing on groundbreaking discoveries in cellular and molecular physiology from the Journal of General Physiology.
Frank Bosmans wrote a commentary of our article, “Tethered spectroscopic probes estimate dynamic distances with subnanometer resolution in voltage-dependent potassium channels,” where he compared the tether length to a dog leash. Longer tethers allow the dog to quench the fluorophore bone, and shorter ones do not. Bosman’s article is titled, “New rule(r)s for FRET.“
Christopher A. Ahern summarizes our recent paper as a “voltage sensor–disabling approach to systematically investigate the identity of the molecular trigger for inactivation and confirm the role for the domain four (DIV S4) voltage sensor in this key physiological process.” Read more in Ahern’s commentary article, “What activates inactivation?“
An introductory video on Linkage analysis by our collaborator, Dan Sigg. This video abstract accompanied two back to back articles in the Journal of General Physiology on the application of Linkage analysis to probe molecular basis of allosteric interactions.
Chowdhury, S. and Chanda, B. (2013) Free-energy relationships in ion channels activated by voltage and ligand.Journal of General Physiology 141(1): 11–28.
Sigg, D (2013) A linkage analysis toolkit for studying allosteric networks in ion channels. Journal of General Physiology 141(1): 29–60.
The Journal of General Physiology published a video abstract for our lab describing how we estimate the free energy change for ion channels. This video relates to our article:
Chowdhury, S., and Chanda, B. (2012) Estimating the voltage-dependent free energy change of ion channels using the median voltage of activation.Journal of General Physiology 139 (1): 3-17.
Ofer Yifrach talks about our recent article in his commentary, “No model in mind: A model-free approach for studying ion
channel gating,” in the Journal of General Physiology.