Our ability to respond rapidly to stimuli such as light, heat, touch, smell and sound is the key to our survival in an ever-changing environment. Electrical phenomenon underlies this fundamental ability to process sensory information and generate complex behavior. The overarching goal of our research is to understand the molecular and cellular basis of electrical signal transduction in biology.

A major focus of our research program is to understand the structural and molecular mechanisms that determine the gating and modulation of voltage-dependent ion channels. Voltage-dependent ion channels are a class of membrane proteins that respond to changes in cellular membrane potential by undergoing a series of conformational rearrangements. These conformational events lead to the opening, closing or inactivation (functionally different from a closed channel) of an ion selective pore domain. Our laboratory utilizes dynamic spectroscopic methods combined with fast voltage-clamp techniques to probe the structure of these short lived intermediates in the gating pathway. These measurements are combined with basic molecular biology and theoretical approaches such as kinetic modeling and molecular simulations to obtain insight into the gating process.

Recent News

Cell paper from the lab!!

Baron's interview is on JGP website.

Chanda Lab in transition

Brian's paper highlighted in Nature Chemical Biology!

Baron Chanda and Sandipan Chowdhury win Cranefield Prizes. Congrats to both!

Brian's paper is highlighted in a commentary

New Addition to Jarecki clan

Ben Haehnal is engaged to LeeAnn Meder. Congratulations, Ben and LeeAnn!!

Debbie and Marcel's latest JGP paper was featured in a commentary by Christopher Ahern.

Kevin Oelstrom was awarded CVRC predoctoral fellowship.

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